DUTCH Adrenal measures adrenal-related hormones using dried urine samples collected across multiple time points in a single day. The test includes daily free cortisol and cortisone patterns, cortisol and cortisone metabolites, and DHEA-S, analysed using LC-MS/MS technology and normalised to creatinine.
These markers are included to provide a layered view of adrenal hormone activity across the day. Free cortisol and cortisone patterns offer insight into daily rhythm and timing, while metabolite measurements reflect overall hormone output. DHEA-S adds additional context around longer-term adrenal hormone production, supporting a more complete interpretation than single-marker testing alone.
Practitioners typically interpret DUTCH Adrenal results alongside symptom patterns, sleep-wake timing, lifestyle factors, stress exposure and other laboratory findings. Results are reviewed in context to understand how daily hormone patterns align with the individual experience of clients.